Metabolic Coupling as a Therapeutic Strategy for Heart Failure
نویسندگان
چکیده
منابع مشابه
Regulating PPARδ signaling as a potential therapeutic strategy for skeletal muscle disorders in heart failure.
DESPITE REMARKABLE improvements in cardiac mortality rates during the past decades (4), poor quality of life remains a major concern for patients with heart failure. One of the determinants of quality of life is exercise tolerance (6). Limited exercise capacity can result from multiple abnormalities in heart failure, which include changes in intramuscular metabolism (20, 21, 28, 46), local infl...
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Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2019
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2019.05.001